Influence of glucocorticoids on time-of-day-dependent variations in IgE-, histamine-, and platelet-activating factor-mediated systemic anaphylaxis in different mouse strains

Biochem Biophys Res Commun. 2018 Jan 15;495(3):2184-2188. doi: 10.1016/j.bbrc.2017.12.099. Epub 2017 Dec 19.

Abstract

A time-of-day-dependent variation in IgE-mediated passive systemic anaphylaxis was previously reported in ICR mice. In the present study, we investigated time-of-day-dependent variations in IgE-, histamine-, and platelet-activating factor (PAF)-mediated systemic anaphylaxis in C57BL/6, BALB/c, and NC/Nga mice at 9:00 h and 21:00 h, and evaluated the potential influence of glucocorticoids (GCs) on these variations. We found significant time-of-day-dependent variations in IgE-mediated systemic anaphylaxis in C57BL/6 mice, and in histamine- and PAF-mediated systemic anaphylaxis in BALB/c mice. Significant daily variations in IgE-, histamine-, and PAF-mediated systemic anaphylaxis were not observed in NC/Nga mice. Pretreatment with dexamethasone and adrenalectomy abolished the daily variations in IgE-mediated systemic anaphylaxis in C57BL/6 mice and in PAF-mediated systemic anaphylaxis in BALB/c mice, suggesting that GCs from adrenal glands are pivotal in regulating these variations. In contrast, pretreatment with dexamethasone and adrenalectomy did not abolish the daily variation in histamine-mediated systemic anaphylaxis in BALB/c mice, suggesting that GC-independent and adrenal gland-independent mechanisms are important for the variation. The present study demonstrated that time-of-day-dependent variations in systemic anaphylaxis differed among inbred mouse strains and with anaphylaxis-inducing substances. Thus, mouse strains, time of experiment, and anaphylaxis-inducing substances used must be considered to obtain appropriate experimental results.

Keywords: Anaphylaxis; Circadian rhythm; Glucocorticoid; Histamine; IgE; Platelet-activating factor.

MeSH terms

  • Anaphylaxis / metabolism*
  • Animals
  • Circadian Rhythm*
  • Disease Models, Animal*
  • Glucocorticoids / metabolism*
  • Histamine / metabolism*
  • Immunoglobulin E / metabolism*
  • Male
  • Mice / classification
  • Mice / metabolism
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Mice, Inbred ICR
  • Platelet Activating Factor / metabolism*
  • Species Specificity

Substances

  • Glucocorticoids
  • Platelet Activating Factor
  • Immunoglobulin E
  • Histamine