Shared cancer neoantigens: Making private matters public

J Exp Med. 2018 Jan 2;215(1):5-7. doi: 10.1084/jem.20172188. Epub 2017 Dec 21.


In this issue of JEM, Chheda et al. ( report that a conserved hotspot mutation associated with an aggressive form of brain cancer generates an immunogenic T cell epitope restricted by a common HLA subtype, thereby creating a "public" neoantigen.

Publication types

  • Comment

MeSH terms

  • Cell- and Tissue-Based Therapy
  • Epitopes, T-Lymphocyte
  • Glioma
  • Histones*
  • Humans
  • Mutation*


  • Epitopes, T-Lymphocyte
  • Histones