Evaluation of a P,N-ligated iridium(I) catalyst in hydrogen isotope exchange reactions of aryl and heteroaryl compounds

Mégane Valero; Annina Burhop; Kristof Jess; Remo Weck; Matthias Tamm; Jens Atzrodt; Volker Derdau

doi:10.1002/jlcr.3595

Evaluation of a P,N-ligated iridium(I) catalyst in hydrogen isotope exchange reactions of aryl and heteroaryl compounds

J Labelled Comp Radiopharm. 2018 Apr;61(4):380-385. doi: 10.1002/jlcr.3595. Epub 2018 Feb 27.

Authors

Mégane Valero¹, Annina Burhop¹, Kristof Jess², Remo Weck¹, Matthias Tamm², Jens Atzrodt¹, Volker Derdau¹

Affiliations

¹ R&D, Integrated Drug Discovery, Isotope Chemistry and Metabolite Synthesis, Sanofi, Frankfurt/Main, Germany.
² Institut für Anorganische und Analytische Chemie, Technische Universität Braunschweig, Braunschweig, Germany.

PMID: 29271003
DOI: 10.1002/jlcr.3595

Abstract

We have developed a novel and efficient iridium-catalyzed hydrogen isotope exchange reaction method with secondary and tertiary sulfonamides at ambient temperatures. Furthermore N-oxides and phosphonamides have been successfully applied in hydrogen isotope exchange reactions with moderate to excellent deuterium introduction.

Keywords: catalysis; deuterium; hydrogen isotope exchange; iridium.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Catalysis
Chemistry Techniques, Synthetic / methods
Deuterium / chemistry*
Iridium / chemistry*
Sulfonamides / chemistry*
Temperature

Substances

Sulfonamides
Iridium
Deuterium