Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to humans. Most existing antimicrobial drugs, including the β-lactam and quinoxiline classes, are not effective against MRSA. In this study, we synthesized 24 derivatives of malonamide, a new class of antibacterial agents and potentiators of classic antimicrobials. A derivative that increases bacterial killing and biofilm eradication with low cell toxicity was created.
Keywords:
Staphylococcus aureus; antibiotics; malonamide.
MeSH terms
-
Anti-Bacterial Agents / chemical synthesis*
-
Anti-Bacterial Agents / pharmacology
-
Biofilms / drug effects*
-
Biofilms / growth & development
-
Cyclopropanes / chemistry*
-
Dicarboxylic Acids / chemistry*
-
Drug Design
-
Humans
-
Malonates / chemical synthesis*
-
Malonates / pharmacology
-
Methicillin-Resistant Staphylococcus aureus / drug effects*
-
Methicillin-Resistant Staphylococcus aureus / growth & development
-
Methicillin-Resistant Staphylococcus aureus / isolation & purification
-
Microbial Sensitivity Tests
-
Staphylococcal Infections / microbiology
-
Structure-Activity Relationship
Substances
-
Anti-Bacterial Agents
-
Cyclopropanes
-
Dicarboxylic Acids
-
Malonates
-
malonamide