[Humanization of Murine Monoclonal anti-hTNF Antibody: The F10 Story]

Mol Biol (Mosk). 2017 Nov-Dec;51(6):1062-1068. doi: 10.7868/S0026898417060167.
[Article in Russian]

Abstract

Tumor necrosis factor (TNF) is a proinflammatory cytokine implicated in pathogenesis of multiple autoimmune and inflammatory diseases. Anti-TNF therapy has revolutionized the therapeutic paradigms of autoimmune diseases and became one of the most successful examples of the clinical use of monoclonal antibodies. Currently, anti-TNF therapy is used by millions of patients worldwide. At the moment, fully human anti-TNF antibody Adalimumab is the best-selling anti-cytokine drug in the world. Here, we present a story about a highly potent anti-TNF monoclonal antibody initially characterized more than 20 years ago and further developed into chimeric and humanized versions. We present comparative analysis of this antibody with Infliximab and Adalimumab.

Keywords: TNF; humanized antibodies; recombinant antibodies; tumor necrosis factor.

Publication types

  • Comparative Study
  • Historical Article

MeSH terms

  • Adalimumab / biosynthesis*
  • Adalimumab / isolation & purification
  • Adalimumab / pharmacology
  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antibodies, Monoclonal / biosynthesis*
  • Antibodies, Monoclonal / history
  • Antibodies, Monoclonal / isolation & purification
  • Antibodies, Monoclonal / pharmacology
  • Antibodies, Monoclonal, Humanized / biosynthesis*
  • Antibodies, Monoclonal, Humanized / history
  • Antibodies, Monoclonal, Humanized / isolation & purification
  • Antibodies, Monoclonal, Humanized / pharmacology
  • Arthritis, Rheumatoid / drug therapy*
  • Arthritis, Rheumatoid / genetics
  • Arthritis, Rheumatoid / immunology
  • Arthritis, Rheumatoid / pathology
  • Cloning, Molecular
  • Gene Expression
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Infliximab / biosynthesis*
  • Infliximab / isolation & purification
  • Infliximab / pharmacology
  • Mice
  • Psoriasis / drug therapy
  • Psoriasis / genetics
  • Psoriasis / immunology
  • Psoriasis / pathology
  • Spondylitis, Ankylosing / drug therapy
  • Spondylitis, Ankylosing / genetics
  • Spondylitis, Ankylosing / immunology
  • Spondylitis, Ankylosing / pathology
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors*
  • Tumor Necrosis Factor-alpha / genetics
  • Tumor Necrosis Factor-alpha / immunology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Tumor Necrosis Factor-alpha
  • Infliximab
  • Adalimumab