Effect of P2 receptor blockade on cutaneous vasodilation during rest and exercise in the heat in young men

Appl Physiol Nutr Metab. 2018 Mar;43(3):312-315. doi: 10.1139/apnm-2017-0700. Epub 2017 Dec 22.


We assessed the role of purinergic P2 receptors in the regulation of cutaneous vasodilation in young adults at rest and during intermittent moderate-intensity exercise in the heat (35 °C). P2 receptor blockade augmented resting cutaneous vasodilation but had no influence during and following exercise. This increase was partly diminished by nitric oxide synthase inhibition. These results suggest a functional role of P2 receptors in the regulation of cutaneous vascular tone during ambient heat exposure at rest.

Keywords: ATP; heat loss; microcirculation; perte de chaleur.

Publication types

  • Clinical Trial

MeSH terms

  • Adult
  • Cross-Over Studies
  • Enzyme Inhibitors / pharmacology
  • Exercise / physiology*
  • Hot Temperature
  • Humans
  • Male
  • NG-Nitroarginine Methyl Ester / administration & dosage
  • NG-Nitroarginine Methyl Ester / pharmacology*
  • Purinergic P2 Receptor Antagonists*
  • Pyridoxine / administration & dosage
  • Pyridoxine / pharmacology*
  • Rest / physiology*
  • Skin Physiological Phenomena / drug effects
  • Vasodilation / drug effects*
  • Vitamin B Complex / pharmacology
  • Young Adult


  • Enzyme Inhibitors
  • Purinergic P2 Receptor Antagonists
  • Vitamin B Complex
  • Pyridoxine
  • NG-Nitroarginine Methyl Ester