Low 25-hydroxyvitamin D levels in postmenopausal female patients with benign paroxysmal positional vertigo

Acta Otolaryngol. 2018 May;138(5):443-446. doi: 10.1080/00016489.2017.1416168. Epub 2017 Dec 22.


Objective: Several studies have reported the association of benign paroxysmal positional vertigo (BPPV) with vitamin D deficiency. This study aimed to evaluate serum 25-hydroxy vitamin D (25 (OH) D) levels in native Chinese postmenopausal women with de novo idiopathic BPPV and to investigate the possible relationship between the occurrence of BPPV and low 25 (OH) D levels.

Methods: This retrospective study comprised of 85 postmenopausal women with de novo idiopathic BPPV and 80 age-matched healthy controls. All subjects had bone mineral density (BMD) and serum 25 (OH) D levels measurements recorded, and the results were compared.

Results: The prevalence of reduced BMD (T score <-1.0) was significantly higher in female patients with BPPV than in healthy controls (71.8% vs. 51.2%, p = .004). The mean serum 25 (OH) D levels were also significantly lower in female patients with BPPV than in healthy controls (19.1 ± 5.2 vs. 22.5 ± 5.8, p < .001). The regression analyses demonstrated that vitamin D deficiency was associated with BPPV with an odds ratio of 2.1 (95% confidence interval = 1.1-3.1, p = .031).

Conclusion: Our study suggests that low 25 (OH) D may be a risk factor for BPPV in postmenopausal women.

Keywords: 25-hydroxy vitamin D; Occurrence; benign paroxysmal positional vertigo; osteopenia; osteoporosis.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Benign Paroxysmal Positional Vertigo / blood*
  • Benign Paroxysmal Positional Vertigo / etiology
  • Bone Density
  • Female
  • Humans
  • Logistic Models
  • Middle Aged
  • Postmenopause / blood
  • Retrospective Studies
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • Vitamin D Deficiency / complications*


  • Vitamin D
  • 25-hydroxyvitamin D