Abstract
Alopecia areata (AA) is an autoimmune disorder characterized by T lymphocytic infiltrates around the bulbar region of hair follicles. Statins have surfaced as potential therapeutic agents for AA, partly because of their modulation of the JAK/STAT pathway. Some data indicate that statins are a possible option for acute, but not chronic, longstanding AA. Animal studies suggest that treatment with statins increases CD4+/CD25+/Foxp3+ populations in AA-affected mice.
Copyright © 2017 The Authors. Published by Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Alopecia Areata / drug therapy*
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Alopecia Areata / immunology
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Animals
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Autoimmune Diseases / drug therapy
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Autoimmune Diseases / immunology
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Cytokines / metabolism
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Ezetimibe, Simvastatin Drug Combination / therapeutic use*
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Humans
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Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
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Mice
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T-Lymphocytes / drug effects
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T-Lymphocytes / immunology
Substances
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Cytokines
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Ezetimibe, Simvastatin Drug Combination
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Hydroxymethylglutaryl-CoA Reductase Inhibitors