The IGF-p53 connection in cancer

Cheryl A Conover

doi:10.1016/j.ghir.2017.11.007

The IGF-p53 connection in cancer

Growth Horm IGF Res. 2018 Apr:39:25-28. doi: 10.1016/j.ghir.2017.11.007. Epub 2017 Dec 2.

Author

Cheryl A Conover¹

Affiliation

¹ Division of Endocrinology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: Conover.Cheryl@mayo.edu.

PMID: 29273484
DOI: 10.1016/j.ghir.2017.11.007

Abstract

Healthy tissue growth depends on a well-controlled and context-appropriate balance of cellular proliferation, cell cycle arrest, and programmed cell death (apoptosis). Disturbance of this balance by activation of oncogenes, inactivation/mutation of tumor suppressor genes, or inhibition of apoptosis can promote tumorigenesis. This mini-review will focus on evidence for the contribution of insulin-like growth factor (IGF) signaling and its regulation by the transcription factor, p53, to tumor development and progression.

Keywords: IGF; IGFBP-3; PAPP-A; Tumor suppressor; p53.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Gene Expression Regulation*
Humans
Insulin-Like Growth Factor I / metabolism*
Neoplasms / physiopathology*
Prognosis
Tumor Suppressor Protein p53 / metabolism*

Substances

Tumor Suppressor Protein p53
Insulin-Like Growth Factor I