Competitive endogenous RNA in colorectal cancer: A systematic review

Han Shuwen; Zhou Qing; Zheng Yan; Yang Xi

doi:10.1016/j.gene.2017.12.036

Competitive endogenous RNA in colorectal cancer: A systematic review

Gene. 2018 Mar 1:645:157-162. doi: 10.1016/j.gene.2017.12.036. Epub 2017 Dec 19.

Authors

Han Shuwen¹, Zhou Qing², Zheng Yan³, Yang Xi⁴

Affiliations

¹ Department of Medical Oncology, Huzhou Central Hospital, Huzhou, Zhejiang Province, China.
² Department of Critical Care Medicine, Huzhou Central Hospital, Huzhou, Zhejiang Province, China.
³ Department of Pathology, Huzhou Central Hospital, Huzhou, Zhejiang Province, China.
⁴ Department of Intervention and Radiotherapy, Huzhou Central Hospital, Huzhou, Zhejiang Province, China. Electronic address: yangxi0601@hotmail.com.

PMID: 29273554
DOI: 10.1016/j.gene.2017.12.036

Abstract

Colorectal cancer is one of the most common malignant tumours. Competitive endogenous RNA (ceRNA) networks have been hypothesized, in which various RNAs regulate each other's expression using microRNA response elements (MREs). Recent evidence has highlighted the crucial regulatory roles of ceRNA networks in colorectal cancer. In this review, we summarize the present research methods as well as the currently known ceRNA competitors and targets in colorectal cancer. In addition, we discuss the significance of ceRNA and shortcomings of current studies of colorectal cancer.

Keywords: Colorectal cancer; RNA; ceRNA; lncRNA; microRNA.

Publication types

Review
Systematic Review

MeSH terms

Colorectal Neoplasms / genetics*
Gene Expression Regulation, Neoplastic
Gene Regulatory Networks
Humans
MicroRNAs / genetics
Pseudogenes / genetics*
RNA / genetics*
RNA, Circular
RNA, Long Noncoding / genetics*
Response Elements

Substances

MicroRNAs
RNA, Circular
RNA, Long Noncoding
RNA