Reproductive events, occurring in adolescence at the time of development of reproductive organs and at the time of tumour initiation, have a bearing on growth characteristics and reproductive hormone regulation in normal and tumour tissue investigated decades later--a hypothesis

Med Hypotheses. 1989 Feb;28(2):93-7. doi: 10.1016/0306-9877(89)90020-0.

Abstract

Both animal and human data indicate that reproductive events taking place early in reproductive life may have an important influence on growth characteristics and reproductive hormone regulation in both normal tissue and neoplastic tissue investigated later in life.

MeSH terms

  • Adolescent
  • Adult
  • Animals
  • Breast Neoplasms / physiopathology*
  • Cell Division
  • Female
  • Humans
  • Mice
  • Middle Aged
  • Neoplasms, Hormone-Dependent / physiopathology*
  • Pregnancy
  • Receptors, Estrogen / physiology*
  • Receptors, Progesterone / physiology*
  • Sexual Maturation
  • Tumor Cells, Cultured / physiology

Substances

  • Receptors, Estrogen
  • Receptors, Progesterone