Multiancestry Association Study Identifies New Asthma Risk Loci That Colocalize With Immune-Cell Enhancer Marks

Nat Genet. 2018 Jan;50(1):42-53. doi: 10.1038/s41588-017-0014-7. Epub 2017 Dec 22.

Abstract

We examined common variation in asthma risk by conducting a meta-analysis of worldwide asthma genome-wide association studies (23,948 asthma cases, 118,538 controls) of individuals from ethnically diverse populations. We identified five new asthma loci, found two new associations at two known asthma loci, established asthma associations at two loci previously implicated in the comorbidity of asthma plus hay fever, and confirmed nine known loci. Investigation of pleiotropy showed large overlaps in genetic variants with autoimmune and inflammatory diseases. The enrichment in enhancer marks at asthma risk loci, especially in immune cells, suggested a major role of these loci in the regulation of immunologically related mechanisms.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Asthma / ethnology
  • Asthma / genetics*
  • Asthma / immunology
  • Enhancer Elements, Genetic*
  • Epigenesis, Genetic
  • Genetic Loci
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Histone Code
  • Humans
  • Leukocytes / metabolism
  • Phenotype
  • Promoter Regions, Genetic
  • Rhinitis, Allergic, Seasonal / genetics
  • Risk