Intestinal microbiome analysis revealed dysbiosis in sickle cell disease

Am J Hematol. 2018 Aug;93(4):E91-E93. doi: 10.1002/ajh.25019. Epub 2018 Jan 9.

Authors

Seah H Lim^{1

2}, Alison Morris³, Kelvin Li³, Adam C Fitch³, Loren Fast¹, Laura Goldberg¹, Matthew Quesenberry¹, Philippa Sprinz⁴, Barbara Methé³

Affiliations

¹ Department of Medicine, Brown University Warren Alpert Medical School, Providence, Rhode Island.
² Department of Medicine, New York Medical College, New York, New York.
³ Center for Medicine and the Microbiome, University of Pittsburgh, Pittsburgh, Pennsylvania.
⁴ Department of Pediatrics, Brown University Warren Alpert Medical School, Providence, Rhode Island.

PMID: 29274089
DOI: 10.1002/ajh.25019

No abstract available

Publication types

Comparative Study
Letter
Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Adult
Aged
Anemia, Sickle Cell / blood
Anemia, Sickle Cell / complications
Anemia, Sickle Cell / immunology
Anemia, Sickle Cell / microbiology*
Bacterial Translocation
Bacteroidetes / isolation & purification*
Blood Cell Count
Blood Sedimentation
Case-Control Studies
Child
Dysbiosis / microbiology*
Female
Fetal Hemoglobin / analysis
Firmicutes / isolation & purification*
Gastrointestinal Microbiome*
Hemoglobin, Sickle / analysis
Humans
Male
Middle Aged
Neutrophil Activation
Proteobacteria / isolation & purification*
Sickle Cell Trait / blood
Sickle Cell Trait / complications
Sickle Cell Trait / immunology
Sickle Cell Trait / microbiology
Young Adult

Substances

Hemoglobin, Sickle
Fetal Hemoglobin