Effects of Photobiomodulation on SOFAT, A T-cell-derived Cytokine, May Explain Accelerated Orthodontic Tooth Movement

Photochem Photobiol. 2018 May;94(3):604-610. doi: 10.1111/php.12878. Epub 2018 Apr 15.


Orthodontic tooth movement is based on mechanical forces inducing bone remodeling, and several methods have been proposed to increase tooth movement, including photobiomodulation. This study evaluated, in an animal model, the effects of photobiomodulation on SOFAT-a secreted osteoclastogenic factor of activated T cells and RANK-L during tooth movement. The results showed that tooth displacement, RANK-L and SOFAT levels were significantly greater compared to Control group. SOFAT may play an important role in bone remodeling during orthodontic movement, possibly increasing the osteoclast cells at the compression area and bone remodeling activity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bone Remodeling
  • Carbon-Oxygen Lyases
  • Cytokines / metabolism*
  • Dental Prosthesis Design
  • Light*
  • Male
  • RANK Ligand / metabolism
  • Rats, Wistar
  • T-Lymphocytes / metabolism*
  • Tooth Movement Techniques


  • Cytokines
  • RANK Ligand
  • Tnfsf11 protein, mouse
  • Carbon-Oxygen Lyases
  • Thnsl2 protein, rat