The Drosophila Gene Torso Encodes a Putative Receptor Tyrosine Kinase

Nature. 1989 Apr 6;338(6215):478-83. doi: 10.1038/338478a0.

Abstract

The maternal gene torso, required for determination of anterior and posterior terminal structures in the Drosophila embryo, was cloned using P-element tagging. Genetic evidence suggests that the action of the gene product is spatially restricted to the terminal regions; the torso messenger RNA, however, is evenly distributed. Structural similarities of the predicted torso protein with growth-factor receptor tyrosine kinases suggest that the spatial restriction of torso activity results from a localized activation of the torso protein at the anterior and posterior egg pole.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Blotting, Northern
  • Cloning, Molecular
  • Drosophila / embryology
  • Drosophila / genetics*
  • ErbB Receptors / genetics*
  • Genes*
  • Molecular Sequence Data
  • Protein-Tyrosine Kinases / genetics*
  • Restriction Mapping

Substances

  • ErbB Receptors
  • Protein-Tyrosine Kinases