Persistence of infectious Friend virus in spleens of mice after spontaneous recovery from virus-induced erythroleukemia

J Virol. 1979 Dec;32(3):832-7. doi: 10.1128/JVI.32.3.832-837.1979.

Abstract

Persistent infectious virus was detected in the majority of spleens of (C57BL/10 X A.BY)F1 mice after spontaneous recovery from Friend virus-induced erythroleukeima. The Friend murine leukemia helper virus (F-MuLV) was detected in titers up to 3 X 10(5) PFU/g of spleen. The defective spleen focus-forming virus (SFFV) was present in much lower titers and could be detected in cell-free spleen homogenates only after amplification of virus titer by growth of virus in vitro on SC1 cells. The incidence of cells producing F-MuLV alone in spleens after recovery from leukemia was 0.003 to 0.3%, and the incidence of cells producing both F-MuLV and SFFV was less than 0.0001 to 0.01%. In most recovered mouse spleens there appeared to be a selective reduction of SFFV relative to F-MuLV.

MeSH terms

  • Animals
  • Bone Marrow / microbiology
  • Defective Viruses / growth & development
  • Friend murine leukemia virus / growth & development*
  • Helper Viruses / growth & development
  • Leukemia, Erythroblastic, Acute / microbiology*
  • Leukemia, Experimental / microbiology*
  • Lymph Nodes / microbiology
  • Mice
  • Spleen / microbiology*
  • Thymus Gland / microbiology