Relationship Between Cavum Septi Pellucidi Measurements and Fetal Hypoplastic Left Heart Syndrome or Dextro-Transposition of the Great Arteries

J Ultrasound Med. 2018 Jul;37(7):1673-1680. doi: 10.1002/jum.14515. Epub 2017 Dec 27.


Objectives: The aim of this study was to compare the size and position of the cavum septi pellucidi (CSP) in fetuses with hypoplastic left heart syndrome (HLHS) or dextro-transposition of the great arteries (d-TGA) with healthy fetuses.

Methods: The CSP length, CSP width, and frontal lobe length were measured in 185 healthy fetuses (404 scans), 11 fetuses with HLHS (16 scans), and 11 fetuses with d-TGA (12 scans) between January 2005 and April 2016. Each measurement was compared between healthy fetuses and those with HLHS or d-TGA, controlling for the biparietal diameter.

Results: Positive correlations were noted between biparietal diameter and CSP length, CSP width, and frontal lobe length (adjusted R2 = 0.811, 0.821, and 0.878, respectively). An increased CSP length was found in both fetuses with HLHS and those with d-TGA (P < .0001). The CSP width was only increased in fetuses with d-TGA (P = .0466). No difference in the frontal lobe length was noted.

Conclusions: In fetuses with HLHS, the CSP is increased in length. In fetuses with d-TGA, the CSP is increased in both length and width.

Keywords: cavum septi pellucidi; dextro-transposition of the great arteries; fetus; hypoplastic left heart syndrome; obstetrics; sonography.

MeSH terms

  • Adult
  • Brain / diagnostic imaging
  • Brain / embryology
  • Female
  • Fetal Heart / diagnostic imaging
  • Humans
  • Hypoplastic Left Heart Syndrome / diagnostic imaging*
  • Pregnancy
  • Retrospective Studies
  • Septum Pellucidum / diagnostic imaging*
  • Transposition of Great Vessels / diagnostic imaging*
  • Ultrasonography, Prenatal / methods*