Pulmonary metastases from autochthonous 3-methylcholanthrene-induced murine tumors

J Natl Cancer Inst. 1979 Dec;63(6):1393-5.


In three experiments, 87%, 75%, and 85% of female C57BL/6N mice developed pulmonary metastases by 50 days after amputation of legs having autochthonous 3-methylcholanthrene-induced sarcomas. No difference in the incidence of pulmonary metastases was observed when autochthonous tumors of short (49--94 days) and longer (95--119 days) latency periods were compared. These metastasizing autochthonous tumors may provide a useful model for studies of metastases and for the evaluation of cancer therapy in a minimal residual disease setting.

MeSH terms

  • Amputation
  • Animals
  • Disease Models, Animal
  • Female
  • Hindlimb
  • Lung Neoplasms / secondary*
  • Methylcholanthrene*
  • Mice
  • Mice, Inbred C57BL
  • Neoplasms, Experimental / secondary
  • Sarcoma, Experimental / chemically induced
  • Sarcoma, Experimental / secondary*
  • Sarcoma, Experimental / surgery


  • Methylcholanthrene