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. 2018 Mar;61(3):216-228.
doi: 10.1002/ajim.22799. Epub 2017 Dec 27.

Occupational Exposure to Textile Dust and Lung Cancer Risk: Results From the ICARE Study

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Occupational Exposure to Textile Dust and Lung Cancer Risk: Results From the ICARE Study

Soumaya Ben Khedher et al. Am J Ind Med. .

Abstract

Background: To investigate the association of lung cancer with occupational exposure to textile dust and specifically to cotton dust in the population-based case-control study ICARE.

Methods: Lifelong occupational history of 2926 cases and 3555 controls was collected using standardized questionnaires, with specific questions for textile dust exposure. Odds ratios (ORs) and 95% confidence intervals (CI) were estimated using unconditional logistic regression models controlling for confounding factors including smoking and asbestos exposure.

Results: An inverse association between textile dust exposure and lung cancer was found among workers exposed ≥5% of their work time (OR = 0.80, 95%CI = 0.58-1.09), more pronounced for distant exposures (40+ years; up to a 56% reduced risk, statistically significant). The OR of lung cancer was significantly decreased among workers exposed to cotton fibers (OR = 0.70, 95%CI = 0.48-0.97).

Conclusions: Our results provide some evidence of a decreased risk of lung cancer associated with exposure to textile dust, particularly cotton.

Keywords: case-control studies; endotoxin; etiology; lung cancer; textile dust.

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