Anti-inflammatory effect of Allium hookeri on carrageenan-induced air pouch mouse model

PLoS One. 2017 Dec 27;12(12):e0190305. doi: 10.1371/journal.pone.0190305. eCollection 2017.


Inflammation is a commonly observed immune reaction, and rheumatoid arthritis is a particularly severe inflammatory disease. In this study, we used an air pouch mouse model to evaluate the anti-inflammatory potential of Allium hookeri, which has both been used as a culinary material and a traditional medicine in south-eastern Asia for many years. Allium hookeri suppressed typical symptoms of inflammation, such as condensation of the air pouch membrane, and inhibited the expression of several inducible proinflammatory cytokines such as IL-1β, IL-6, IL-13, and TNF-α. In order to determine the molecules modulating the inflammatory effect of carrageenan treatment, the components in Allium hookeri were analyzed by GC-MS, and linoleic acid, which have anti-inflammatory effect, was detected. From the results, we concluded that the anti-inflammatory effect of Allium hookeri might be attributed to linoleic acid, which could be promising candidates for anti-inflammatory drugs that have no adverse effects.

MeSH terms

  • Allium / metabolism*
  • Animals
  • Carrageenan / toxicity*
  • Cytokines / metabolism
  • Inflammation / chemically induced
  • Inflammation / metabolism
  • Inflammation / prevention & control*
  • Inflammation Mediators / metabolism
  • Mice


  • Cytokines
  • Inflammation Mediators
  • Carrageenan

Grant support

The authors received no specific funding for this work.