Metabolic Models of Protein Allocation Call for the Kinetome

Avlant Nilsson; Jens Nielsen; Bernhard O Palsson

doi:10.1016/j.cels.2017.11.013

Metabolic Models of Protein Allocation Call for the Kinetome

Cell Syst. 2017 Dec 27;5(6):538-541. doi: 10.1016/j.cels.2017.11.013.

Authors

Avlant Nilsson¹, Jens Nielsen², Bernhard O Palsson³

Affiliations

¹ Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE412 96 Gothenburg, Sweden.
² Department of Biology and Biological Engineering, Chalmers University of Technology, Kemivägen 10, SE412 96 Gothenburg, Sweden; Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Hørsholm DK2970, Denmark. Electronic address: nielsenj@chalmers.se.
³ Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Hørsholm DK2970, Denmark; Departments of Bioengineering and Pediatrics, Mail Code 412, University of California, San Diego, La Jolla, CA 92093, USA.

PMID: 29284126
DOI: 10.1016/j.cels.2017.11.013

Abstract

The flux of metabolites in the living cell depend on enzyme activities. Recently, many metabolic phenotypes have been explained by computer models that incorporate enzyme activity data. To move further, the scientific community needs to measure the kinetics of all enzymes in a systematic way.

MeSH terms

Animals
Biological Evolution
Computational Biology*
Computer Simulation*
Enzyme Activation*
Humans
Kinetics
Models, Biological*
Models, Theoretical*
Proteins / metabolism*
Whole Genome Sequencing

Substances

Proteins