Cross-sectional Analyses of Participation in Cancer Screening and Use of Hormone Replacement Therapy and Medications in Meat Eaters and Vegetarians: The EPIC-Oxford Study

BMJ Open. 2017 Dec 27;7(12):e018245. doi: 10.1136/bmjopen-2017-018245.

Abstract

Objectives: To examine differences in health-related behaviours such as screening or testing for cancer, use of hormone replacement therapy (HRT) and use of other medications in different diet groups.

Design: We studied 31 260 participants across four diet groups (18 155 meat eaters, 5012 fish eaters, 7179 vegetarians, 914 vegans) in the UK EPIC-Oxford cohort. Information was collected in 5-year (around 2000-2003) or 10-year (around 2007) follow-up questionnaires regarding participation in breast screening, cervical screening, prostate-specific antigen (PSA) testing, use of HRT and use of medications for the past 4 weeks. Using Poisson regression, we estimated the prevalence ratios (PR) for each behaviour across people of different diet groups, using meat eaters as the reference group.

Results: Compared with meat eaters, vegetarian (PR: 0.94, 95% CI 0.89 to 0.98) and vegan (PR: 0.82, 95% CI 0.71 to 0.95) women reported lower participation in breast screening, and vegetarian men were less likely to report PSA testing (PR: 0.82, 95% CI 0.71 to 0.96). No differences were observed among women for cervical screening. In women, all non-meat-eating groups reported lower use of HRT compared with meat eaters (P heterogeneity <0.0001). Lower reported use of any medication was observed for participants in all non-meat-eating groups with no (P<0.0001) or one (P=0.0002) self-reported illness. No heterogeneity was observed across the diet groups for the reported use of specific medication for high blood pressure, high blood cholesterol, asthma, diabetes and thyroid disease.

Conclusions: Differences in self-reported breast screening, PSA testing, HRT use and overall medication use were observed across the diet groups. Whether such differences contribute to differential long-term disease risks requires further study.

Keywords: oncology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Animals
  • Cohort Studies
  • Cross-Sectional Studies
  • Diet*
  • Early Detection of Cancer / statistics & numerical data*
  • Female
  • Hormone Replacement Therapy / statistics & numerical data*
  • Humans
  • Male
  • Middle Aged
  • Neoplasms / classification
  • Neoplasms / diagnosis*
  • Seafood
  • United Kingdom
  • Vegetarians