A new phenylspirodrimane dimer from the fungus Stachybotrys chartarum

Zhang-Gui Ding; Jian-Hai Ding; Jiang-Yuan Zhao; Wei-Xun Chunyu; Ming-Gang Li; Shao-Jie Gu; Fei Wang; Meng-Liang Wen

doi:10.1016/j.fitote.2017.12.022

A new phenylspirodrimane dimer from the fungus Stachybotrys chartarum

Fitoterapia. 2018 Mar:125:94-97. doi: 10.1016/j.fitote.2017.12.022. Epub 2017 Dec 26.

Authors

Zhang-Gui Ding¹, Jian-Hai Ding², Jiang-Yuan Zhao¹, Wei-Xun Chunyu¹, Ming-Gang Li¹, Shao-Jie Gu³, Fei Wang⁴, Meng-Liang Wen⁵

Affiliations

¹ Key Laboratory for Microbial Resources, Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, PR China.
² Key Laboratory for Microbial Resources, Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, PR China; Engineering and Technology Research Center of Liupanshan Resources, College of Chemistry and Chemical Engineering, Ningxia Normal University, Guyuan, Ningxia 756000, PR China. Electronic address: 82008016@nxnu.edu.cn.
³ BioBioPha Co., Ltd., Kunming 650201, PR China.
⁴ BioBioPha Co., Ltd., Kunming 650201, PR China. Electronic address: f.wang@mail.biobiopha.com.
⁵ Key Laboratory for Microbial Resources, Ministry of Education, Yunnan Institute of Microbiology, Yunnan University, Kunming 650091, PR China. Electronic address: mlwen@ynu.edu.cn.

PMID: 29288026
DOI: 10.1016/j.fitote.2017.12.022

Abstract

A new phenylspirodrimane dimer, named stachartarin A (1), was isolated from cultures of the tin mine tailings-associated fungus Stachybotrys chartarum. Its structures were elucidated by means of spectroscopic methods. At the same time, the compound was tested for its cytotoxicity against HL-60, SMMC-7721, A-549, MCF-7, and SW480 cells.

Keywords: Cytotoxicity; Phenylspirodrimane dimer; Secondary metabolites; Stachybotrys chartarum.

MeSH terms

Cell Line, Tumor
Humans
Mining
Molecular Structure
Secondary Metabolism
Spiro Compounds / isolation & purification*
Stachybotrys / chemistry*
Tin

Substances

Spiro Compounds
Tin