New diterpenes from Nigella damascena seeds and their antiviral activities against herpes simplex virus type-1

J Nat Med. 2018 Mar;72(2):439-447. doi: 10.1007/s11418-017-1166-6. Epub 2017 Dec 29.


Nigella species are rich source of dolabellane diterpenes. During our study of Nigella species, new dolabellane diterpenes, damasterpenes V-VIII were isolated. The structural determination of new compounds damasterpenes V-VIII is described with consideration of their absolute configurations. The antiviral activities against herpes simplex virus type-1 of the isolated compounds and their derivatives are also evaluated. Damasterpene V (inhibition 35.0%) and 2-phenylacetyl 13-benzoyl damasterpenol (32.0%) showed significant antiviral activity at 10 μM.

Keywords: Antiviral activity; Diterpene; HSV-1; Nigella damascena; Ranunculaceae.

MeSH terms

  • Antiviral Agents / pharmacology
  • Antiviral Agents / therapeutic use*
  • Diterpenes / chemistry*
  • Herpesvirus 1, Human / drug effects*
  • Nigella damascena / chemistry*
  • Seeds / chemistry*


  • Antiviral Agents
  • Diterpenes