Cryobiopsy versus forceps biopsy in endobronchial lesions, diagnostic yield and safety

Adv Respir Med. 2017;85(6):301-306. doi: 10.5603/ARM.2017.0052.


Introduction: This study aimed to evaluate the safety and diagnostic yield of CB in comparison to forceps biopsy in endobronchial lesions.

Material and methods: Patients with suspected endobronchial lesions were enrolled. Two forceps biopsies and one cryobiopsy were done in the same patient with randomized sequence. The largest diameter of the samples was measured in mm by electronic caliper. Diagnostic yield of each technique and postbronchoscopy bleeding were evaluated.

Results: Samples obtained by CB was significantly larger than that of the forceps biopsy (5.9 ± 2.3 vs 2.5 ± 0.8), (p = 0.001). Diagnostic yield of CB was significantly higher than forceps biopsy 74.5% versus 51.1% (p = 0.001). Mild and moderate bleeding grades were reported in both techniques with no significant difference (p = 0.063) (p = 0.5) respectively. Severe bleeding was not recorded in both techniques.

Conclusions: CB represents a safe and effective tool to obtain a larger tissue samples of a good quality with higher diagnostic yield in comparison to standard forceps samples. On the other hand, bleeding occurred more frequently after CB than forceps biopsy. However, without severe adverse effects.

Keywords: bronchoscopy; cryobiopsy; endobronchial lesion; forceps biopsy; lung cancer.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Biopsy / methods*
  • Bronchial Neoplasms / diagnosis*
  • Bronchial Neoplasms / pathology
  • Bronchoscopy / methods*
  • Cryosurgery / methods*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Prospective Studies
  • Surgical Instruments