Effects of dietary advice on insulin-like growth factors among healthy newborns

Arch Gynecol Obstet. 2018 Mar;297(3):637-643. doi: 10.1007/s00404-017-4645-9. Epub 2017 Dec 30.


Objectives: In fetal life, insulin, insulin-like growth factor (IGF) 1, IGF 2 and IGF-binding protein (IGFBP) 3 are essential growth factors. The purpose of this study is to investigate the effects of dietary intervention on insulin-like growth factors in the cord blood of neonates.

Methods: The study involved 52 pregnant women who were followed up in Gazi University Medical School Hospital at Ankara, Turkey. They were randomly divided into two groups: The experimental group was involved in nutrition education. We measured IGF 1, IGF 2 and IGFBP 3 concentrations in cord blood from 52 neonates.

Results: In the experimental group, cord serum levels of IGF 1, IGF 2 were observed to be higher than that of control group.

Conclusion: Dietary advice had positive effects on the cord serum IGF 1 and IGF 2 concentrations. Dietary advice during pregnancy proved to be effective in fetal development.

Keywords: Anthropometry; Dietary advice; Insulin-like growth factors; Newborns; Pregnancy.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Birth Weight
  • Counseling
  • Dietary Proteins
  • Female
  • Fetal Blood / metabolism*
  • Fetal Development / physiology
  • Humans
  • Infant, Newborn
  • Insulin / metabolism
  • Insulin-Like Growth Factor Binding Protein 3 / blood
  • Insulin-Like Growth Factor Binding Protein 3 / metabolism*
  • Insulin-Like Growth Factor I / metabolism*
  • Insulin-Like Growth Factor II / metabolism*
  • Pregnancy
  • Pregnant Women
  • Recombinant Proteins
  • Turkey


  • Dietary Proteins
  • Insulin
  • Insulin-Like Growth Factor Binding Protein 3
  • Recombinant Proteins
  • Insulin-Like Growth Factor I
  • Insulin-Like Growth Factor II
  • mecasermin