The overdriven glomerulus as a cardiovascular risk factor

Kidney Int. 2018 Jan;93(1):13-15. doi: 10.1016/j.kint.2017.08.035.


In a large cohort of patients referred for the diagnosis of hypertension by ambulatory blood pressure monitoring, the risk for cardiovascular events associated with glomerular hyperfiltration (hazard ratio: 1.53) was higher than that associated with diabetes (hazard ratio: 1.43) or with a 10 mm Hg higher 24-hour systolic blood pressure (hazard ratio: 1.37) and was identical to that by smoking (hazard ratio: 1.53). Reducing glomerular hyperfiltration may improve cardiovascular outcomes in hypertensive patients, an issue that remains to be tested in appropriate randomized clinical trials.

Publication types

  • Comment

MeSH terms

  • Antihypertensive Agents
  • Blood Pressure / drug effects
  • Blood Pressure Monitoring, Ambulatory*
  • Cardiovascular Diseases*
  • Humans
  • Hypertension
  • Risk Factors


  • Antihypertensive Agents