Antibiotic treatment insufficient for established septic arthritis. Staphylococcus aureus experiments in rabbits

Acta Orthop Scand. 1989 Feb;60(1):113-5. doi: 10.3109/17453678909150107.


We treated septic arthritis of the knee in 38 rabbits with cloxacillin i.m. once and twice daily combined with probenecid for 7 or 21 days, respectively, or with only cloxacillin i.m. thrice daily for 7 days. The animals were killed weekly in groups up to 5 weeks after inoculation. Aspirated cultures obtained after 4 days of treatment were always negative. Histologic specimens revealed progressive joint destruction, but at a slower rate after frequent treatment independent of the period. We concluded that antibiotic therapy alone could not prevent destruction of articular cartilage once bacterial arthritis was established.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arthritis, Infectious / drug therapy*
  • Arthritis, Infectious / microbiology
  • Arthritis, Infectious / pathology
  • Cloxacillin / administration & dosage
  • Cloxacillin / therapeutic use*
  • Drug Therapy, Combination
  • Knee Joint / microbiology
  • Knee Joint / pathology
  • Probenecid / administration & dosage
  • Probenecid / therapeutic use
  • Rabbits
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / microbiology
  • Staphylococcal Infections / pathology


  • Cloxacillin
  • Probenecid