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. 2018 Feb:112:310-319.
doi: 10.1016/j.fct.2017.12.066. Epub 2017 Dec 30.

Detoxification of trichothecene mycotoxins by a novel bacterium, Eggerthella sp. DII-9

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Detoxification of trichothecene mycotoxins by a novel bacterium, Eggerthella sp. DII-9

Xiaojuan Gao et al. Food Chem Toxicol. 2018 Feb.

Abstract

Trichothecene mycotoxins are a group of structurally related sesquiterpenoid metabolites produced by multiple Fusarium species that often contaminate cereals and threaten human and animal health. The basic structure of this mycotoxin group is a characteristic 12, 13-epoxide group, which is considered an essential functional group for toxicity. In this study, using trichothecene mycotoxin deoxynivalenol (DON) as a representative substrate, we identified a novel trichothecene deepoxidation bacterium, Eggerthella sp. DII-9 (DII-9), from chicken intestines. DII-9 can grow and transform DON over abroad range of temperatures (20-45 °C) and pH values (5-10), suggesting the possibility of developing promising future applications as feed additives. Substrate specificity analysis showed that DII-9 is capable of promoting the deepoxidation of DON, HT-2, T-2 triol and T-2 tetraol. To explore the molecular mechanisms of the de-epoxidation of trichothecenes, the complete genome of DII-9 was sequenced and characterized. Altogether, a novel detoxification bacterium for trichothecene mycotoxins was identified and characterized.

Keywords: De-epoxidation; Eggerthella sp. DII-9; Genome; Trichothecenes.

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