Clinical Success of Drug Targets Prospectively Predicted by In Silico Study

Trends Pharmacol Sci. 2018 Mar;39(3):229-231. doi: 10.1016/ Epub 2017 Dec 30.


The selection of the right drug targets is critically important for the successful and cost-effective development and clinical testing of drugs. A 2009 paper reported an in silico prospective prediction of the clinical potential of 156 targets of clinical trial drugs (all of these targets were without an approved drug at the time of the paper's publication). Eight years later, the assessment of the clinical status of these targets revealed impressive capability of the in silico method in prospectively predicting the clinical success of drug targets.

Keywords: clinical trial; in silico methods; target discovery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Clinical Trials as Topic
  • Computer Simulation*
  • Drug Discovery / methods*
  • Humans
  • Molecular Targeted Therapy / methods*