Activated protein C light chain provides an extended binding surface for its anticoagulant cofactor, protein S

Blood Adv. 2017 Aug 7;1(18):1423-1426. doi: 10.1182/bloodadvances.2017007005. eCollection 2017 Aug 8.


Protein S anticoagulant cofactor sensitivity and PAR1 cleavage activity were assayed for 9 recombinant APC mutants.Residues L38, K43, I73, F95, and W115 on one face of the APC light chain define an extended surface containing the protein S binding site.