Non-natural amino acid peptide microarrays to discover Ebola virus glycoprotein ligands

Chem Commun (Camb). 2018 Feb 6;54(12):1417-1420. doi: 10.1039/c7cc08242h.

Abstract

We demonstrate a platform to screen a virus pseudotyped with Ebola virus glycoprotein (GP) against a library of peptides that contain non-natural amino acids to develop GP affinity ligands. This system could be used for rapid development of peptide-based antivirals for other emerging or neglected tropical infectious diseases.

MeSH terms

  • Amino Acids / chemistry*
  • Amino Acids / metabolism*
  • Antiviral Agents / analysis
  • Antiviral Agents / metabolism
  • Drug Discovery / methods*
  • Ebolavirus / metabolism*
  • Ligands
  • Peptides / chemistry
  • Peptides / metabolism*
  • Protein Array Analysis*
  • Viral Envelope Proteins / metabolism*

Substances

  • Amino Acids
  • Antiviral Agents
  • Ligands
  • Peptides
  • Viral Envelope Proteins
  • envelope glycoprotein, Ebola virus