The Apolipoprotein M/S1P Axis Controls Triglyceride Metabolism and Brown Fat Activity

Cell Rep. 2018 Jan 2;22(1):175-188. doi: 10.1016/j.celrep.2017.12.029.


Apolipoprotein M (apoM) is the carrier of sphingosine-1-phosphate (S1P) in plasma high-density lipoproteins. S1P is a bioactive lipid interacting with five receptors (S1P1-5). We show that lack of apoM in mice increases the amount of brown adipose tissue (BAT), accelerates the clearance of postprandial triglycerides, and protects against diet-induced obesity (i.e., a phenotype similar to that induced by cold exposure or β3-adrenergic stimulation). Moreover, the data suggest that the phenotype of apoM-deficient mice is S1P dependent and reflects diminished S1P1 stimulation. The results reveal a link between the apoM/S1P axis and energy metabolism.

Keywords: apoM; apolipoproteins; brown adipose tissue; lipid metabolism; lipoproteins; sphingolipids; sphingosine-1-phosphate; triglyceride.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue, Brown / cytology
  • Adipose Tissue, Brown / metabolism*
  • Animals
  • Apolipoproteins M / genetics
  • Apolipoproteins M / metabolism*
  • Energy Metabolism / physiology*
  • Lysophospholipids / genetics
  • Lysophospholipids / metabolism*
  • Mice
  • Mice, Knockout
  • Sphingosine / analogs & derivatives*
  • Sphingosine / genetics
  • Sphingosine / metabolism
  • Triglycerides / metabolism*


  • ApoM protein, mouse
  • Apolipoproteins M
  • Lysophospholipids
  • Triglycerides
  • sphingosine 1-phosphate
  • Sphingosine