Effects of bone marrow aspirate concentrate and platelet-rich plasma on patients with partial tear of the rotator cuff tendon

J Orthop Surg Res. 2018 Jan 3;13(1):1. doi: 10.1186/s13018-017-0693-x.


Background: We compared the clinical course of rotator cuff tears between rotator cuff exercise and bone marrow aspirate concentration (BMAC)-platelet rich plasma (PRP) injection to identify the therapeutic effects of BMAC-PRP on partial tear of the rotator cuff tendon.

Methods: Twenty-four patients with partial tear of the rotator cuff tendon participated in this study. Twelve patients underwent extraction of BMACs and PRP and received the injection of BMAC-PRP at the tear site under ultrasound guidance. Twelve patients in the control group were asked to perform the rotator cuff exercise for 3 months. Visual analog scale (VAS) and manual muscle test (MMT) scores of the supraspinatus muscle were measured, and the American Shoulder and Elbow Surgeons (ASES) score was recorded before, 3 weeks, and 3 months after injection. Tear size was measured by the greatest longitudinal tear length.

Results: The change in the VAS differed between groups at 3 months (P = 0.039) but not at 3 weeks (P = 0.147). The ASES scores in the BMAC-PRP group changed from 39.4 ± 13.0 to 54.5 ± 11.5 at 3 weeks and 74.1 ± 8.5 at 3 months while those in the control group changed from 45.9 ± 12.4 to 56.3 ± 12.3 at 3 weeks (P = 0.712) and 62.2 ± 12.2 at 3 months (P = 0.011). The tear size decreased at 3 weeks or 3 months after the BMAC-PRP injection but was not significantly different from that in the control group.

Conclusions: BMAC-PRP improved pain and shoulder function in patients with partial tear of the rotator cuff tendon.

Trial registration: The patients were registered in the institutional board registry of Samsung Medical Center (registry number 2014-07-173 ).

Keywords: Bone marrow aspirates; Degeneration; Platelet-rich plasma; Rotator cuff tear.

Publication types

  • Controlled Clinical Trial

MeSH terms

  • Aged
  • Bone Marrow Transplantation / methods*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Paracentesis
  • Platelet-Rich Plasma*
  • Prospective Studies
  • Rotator Cuff Injuries / diagnostic imaging
  • Rotator Cuff Injuries / physiopathology
  • Rotator Cuff Injuries / therapy*
  • Shoulder Joint / physiopathology
  • Single-Blind Method
  • Ultrasonography, Interventional / methods
  • Visual Analog Scale