The Suppressive Activity of Fucofuroeckol-A Derived from Brown Algal Ecklonia stolonifera Okamura on UVB-Induced Mast Cell Degranulation

Mar Drugs. 2018 Jan 4;16(1):1. doi: 10.3390/md16010001.

Abstract

UV light, especially UVB, is known as a trigger of allergic reaction, leading to mast cell degranulation and histamine release. In this study, phlorotannin Fucofuroeckol-A (F-A) derived from brown algal Ecklonia stolonifera Okamura was evaluated for its protective capability against UVB-induced allergic reaction in RBL-2H3 mast cells. It was revealed that F-A significantly suppress mast cell degranulation via decreasing histamine release as well as intracellular Ca2+ elevation at the concentration of 50 μM. Moreover, the inhibitory effect of F-A on IL-1β and TNF-α productions was also evidenced. Notably, the protective activity of F-A against mast cell degranulation was found due to scavenging ROS production. Accordingly, F-A from brown algal E. stolonifera was suggested to be promising candidate for its protective capability against UVB-induced allergic reaction.

Keywords: Ecklonia stolonifera; Fucofuroeckol-A; anti-allergy; degranulation; mast cells; phlorotannin.

MeSH terms

  • Animals
  • Anti-Allergic Agents / chemistry
  • Anti-Allergic Agents / isolation & purification
  • Anti-Allergic Agents / pharmacology*
  • Benzofurans / chemistry
  • Benzofurans / isolation & purification
  • Benzofurans / pharmacology*
  • Calcium / metabolism
  • Cell Degranulation / drug effects*
  • Cell Degranulation / radiation effects
  • Cell Line, Tumor
  • Dioxins / chemistry
  • Dioxins / isolation & purification
  • Dioxins / pharmacology*
  • Free Radical Scavengers / isolation & purification
  • Free Radical Scavengers / pharmacology
  • Histamine / metabolism
  • Interleukin-1beta / antagonists & inhibitors
  • Mast Cells / drug effects*
  • Mast Cells / metabolism
  • Mast Cells / radiation effects
  • Phaeophyta / metabolism*
  • Rats
  • Reactive Oxygen Species / metabolism
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • Ultraviolet Rays / adverse effects

Substances

  • Anti-Allergic Agents
  • Benzofurans
  • Dioxins
  • Free Radical Scavengers
  • Interleukin-1beta
  • Reactive Oxygen Species
  • Tumor Necrosis Factor-alpha
  • fucofuroeckol-A
  • Histamine
  • Calcium