Dietary Supplements: Regulatory Challenges and Research Resources

Nutrients. 2018 Jan 4;10(1):41. doi: 10.3390/nu10010041.


Many of the scientific and regulatory challenges that exist in research on the safety, quality and efficacy of dietary supplements are common to all countries as the marketplace for them becomes increasingly global. This article summarizes some of the challenges in supplement science and provides a case study of research at the Office of Dietary Supplements at the National Institutes of Health, USA, along with some resources it has developed that are available to all scientists. It includes examples of some of the regulatory challenges faced and some resources for those who wish to learn more about them.

Keywords: National Institutes of Health; Office of Dietary Supplements; complementary medicine; dietary supplements; food supplements; natural health product; regulatory challenges; scientific challenges; supplement science; traditional medicines.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomedical Research / legislation & jurisprudence*
  • Biomedical Research / standards
  • Consumer Product Safety / legislation & jurisprudence
  • Dietary Supplements* / adverse effects
  • Dietary Supplements* / classification
  • Dietary Supplements* / standards
  • Government Regulation
  • Health Policy / legislation & jurisprudence*
  • Humans
  • Policy Making
  • Quality Control
  • Risk Assessment
  • Terminology as Topic