Phase-Amplitude Coupling: A General Mechanism for Memory Processing and Synaptic Plasticity?

Neuron. 2018 Jan 3;97(1):10-13. doi: 10.1016/j.neuron.2017.12.023.


In this issue of Neuron, Helfrich et al. (2017) demonstrate that phase-amplitude coupling (PAC) between slow oscillations and spindles is crucial for memory consolidation, and shifts in its phase relationship may explain age-related deficits in memory performance. These results also suggest a more general function of PAC in synaptic plasticity.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Atrophy
  • Brain
  • Humans
  • Memory
  • Neuronal Plasticity*
  • Sleep*