Modeling psychiatric disorders using patient stem cell-derived neurons: a way forward

Genome Med. 2018 Jan 4;10(1):1. doi: 10.1186/s13073-017-0512-3.


Our understanding of the neurobiology of psychiatric disorders remains limited, and biomarker-based clinical management is yet to be developed. Induced pluripotent stem cell (iPSC) technology has revolutionized our capacity to generate patient-derived neurons to model psychiatric disorders. Here, we highlight advantages and caveats of iPSC disease modeling and outline strategies for addressing current challenges.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Humans
  • Induced Pluripotent Stem Cells / pathology*
  • Mental Disorders / genetics
  • Mental Disorders / pathology*
  • Models, Biological*
  • Neurons / pathology*