EUS dating with laser ablation against the caudate lobe or left liver tumors: a win-win proposition?

Cancer Biol Ther. 2018 Mar 4;19(3):145-152. doi: 10.1080/15384047.2017.1414760. Epub 2018 Jan 25.

Abstract

Endoscopic ultrasound (EUS) have been not only a diagnostic tool, but also available in interventional therapy, which often previously needed surgical approaches to achieve. The study aimed to evaluate the effectiveness and safety of EUS-guided Nd:YAG laser ablation in unresectable tumors of the caudate lobe and left liver. We discussed ten cases of the caudate lobe and left liver tumors underwent laser ablation with EUS guidance. And we also have reviewed previous publication of EUS-guided thermal ablation for liver tumors in several decade years. EUS-guided Nd:YAG laser ablation (LA) of these tumors were successfully completed in ten patients, who had favourable prognosis with no complications in two-month follow-up. Based on our early observations, this suggested that EUS-guided LA might be technically feasible in selected patients with tumors of the caudate lobe and left liver. However, the safety of this technique need to be further confirmed in the future and if possible larger, prospective trials.

Keywords: Ablation; endoscopic ultrasonography; intervention EUS; laser ablation; liver; tumor; ultrasonography.

Publication types

  • Observational Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Endosonography / adverse effects
  • Endosonography / methods*
  • Feasibility Studies
  • Female
  • Humans
  • Laser Therapy / adverse effects
  • Laser Therapy / instrumentation
  • Laser Therapy / methods*
  • Lasers, Solid-State / therapeutic use
  • Liver / diagnostic imaging
  • Liver / pathology
  • Liver / surgery
  • Liver Neoplasms / diagnostic imaging
  • Liver Neoplasms / surgery*
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Prospective Studies
  • Treatment Outcome
  • Ultrasonography, Interventional / adverse effects
  • Ultrasonography, Interventional / methods*

Grants and funding

The opening foundation of State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital of Medical College, Zhejiang University (2015KF06), and the Foundation of Zhejiang Health Committee (2017KY346).