The prohibitin-binding compound fluorizoline induces apoptosis in chronic lymphocytic leukemia cells ex vivo but fails to prevent leukemia development in a murine model

Haematologica. 2018 Apr;103(4):e154-e157. doi: 10.3324/haematol.2017.175349. Epub 2018 Jan 5.

Authors

Marina Wierz¹, Sandrine Pierson¹, Nora Chouha², Laurent Désaubry², Jean-Hugues François³, Guy Berchem^{1

3}, Jerome Paggetti⁴, Etienne Moussay⁴

Affiliations

¹ Laboratory of Experimental Cancer Research, Department of Oncology, Luxembourg Institute of Health, Luxembourg.
² Laboratory of Therapeutic Innovation (UMR 7200) CNRS/Université de Strasbourg, Faculté de Pharmacie, Illkirch, Luxembourg.
³ Centre Hospitalier de Luxembourg, Luxembourg.
⁴ Laboratory of Experimental Cancer Research, Department of Oncology, Luxembourg Institute of Health, Luxembourg jerome.paggetti@lih.lu etienne.moussay@lih.lu.

No abstract available

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Apoptosis / drug effects*
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / drug therapy
Leukemia, Lymphocytic, Chronic, B-Cell / pathology*
Mice
Prohibitins
Proto-Oncogene Proteins c-bcl-2 / genetics
Repressor Proteins / metabolism*
Thiazoles / metabolism
Thiazoles / pharmacology*
Transcriptional Activation / drug effects
Tumor Cells, Cultured

Substances

PMAIP1 protein, human
Prohibitins
Proto-Oncogene Proteins c-bcl-2
Repressor Proteins
Thiazoles