5-Chloro-substituted derivatives of 2', 3'-didehydro-2',3'-dideoxyuridine, 3'-fluoro-2',3'-dideoxyuridine and 3'-azido-2',3'-dideoxyuridine as anti-HIV agents

Biochem Pharmacol. 1989 Mar 15;38(6):869-74. doi: 10.1016/0006-2952(89)90273-6.

Authors

J Balzarini¹, A van Aerschot, P Herdewijn, E de Clercq

Affiliation

¹ Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.

PMID: 2930588
DOI: 10.1016/0006-2952(89)90273-6

No abstract available

Publication types

Comparative Study

MeSH terms

Animals
Antiviral Agents*
Cell Line
Dideoxynucleosides / chemical synthesis*
Dideoxynucleosides / pharmacology
HIV / drug effects*
Humans
Kinetics
Thymidine Kinase / antagonists & inhibitors
Virus Replication / drug effects*
Zidovudine / analogs & derivatives
Zidovudine / pharmacology

Substances

Antiviral Agents
Dideoxynucleosides
3'-fluoro-2',3'-dideoxyuridine
Zidovudine
2',3'-didehydro-2',3'-dideoxyuridine
Thymidine Kinase
3'-azido-2',3'-dideoxyuridine