Sarcomatoid renal cell carcinoma: Biology and treatment advances

Urol Oncol. 2018 Jun;36(6):265-271. doi: 10.1016/j.urolonc.2017.12.012. Epub 2018 Jan 3.


Sarcomatoid transformation in renal cell carcinoma, so called sacromatoid RCC (sRCC), is associated with an aggressive behavior and a poor prognosis. Current therapeutic approaches are largely ineffective. Recent studies looking into the genomic and molecular characterization of sRCCs have provided insights into the biology and pathogenesis of this entity. These advances in molecular signatures may help development of effective treatment strategies. We herein present a review of recent developments in the pathology, biology, and treatment modalities in sRCC.

Keywords: Chemotherapy; Immunotherapy; Nephrectomy; Renal cell carcinoma; Sarcomatoid renal cell carcinoma; Targeted therapy.

Publication types

  • Review

MeSH terms

  • Carcinoma, Renal Cell / pathology*
  • Carcinoma, Renal Cell / therapy*
  • Humans
  • Kidney Neoplasms / pathology*
  • Kidney Neoplasms / therapy*
  • Sarcoma / pathology*
  • Sarcoma / therapy*
  • Treatment Outcome