Rice bran supplement prevents UVB-induced skin photoaging in vivo

Biosci Biotechnol Biochem. 2018 Feb;82(2):320-328. doi: 10.1080/09168451.2017.1417021. Epub 2018 Jan 8.


Although rice bran consumption is reportedly has numerous beneficial effects on human health, the relationship between rice bran and the prevention of photoaging has not been investigated in detail. We sought to investigate whether consumption of rice bran supplement (RBS) can elicit preventive effects against UVB-induced photoaging in vivo. Dorsal skin sections of hairless mice were exposed to UVB over 16 weeks. RBS consumption suppressed UVB-induced wrinkle formation and inhibited the loss of water content and epidermal thickening in the mouse skin. Western blot and immunohistochemical analyses revealed that repeated exposure to UVB upregulated matrix metalloproteinase-13 (MMP-13) and cyclooxygenase-2 (COX-2) expression, while consumption of RBS suppressed MMP-13 and COX-2 expression, as well as mitogen-activated protein kinase (MAPK) signaling pathways. These findings suggest that RBS could be a potential bioactive ingredient in nutricosmetics to inhibit wrinkle formation and water content loss via the suppression of COX-2 and MMP-13 expression.

Keywords: Rice bran supplement (RBS); anti-wrinkle; cyclooxygenase-2 (COX-2); matrix metalloproteinase-13 (MMP-13); photoaging.

MeSH terms

  • Animals
  • Cyclooxygenase 2 / metabolism
  • Dietary Supplements*
  • Epidermis / drug effects
  • Epidermis / pathology
  • Epidermis / radiation effects
  • Female
  • Gene Expression Regulation, Enzymologic / drug effects
  • Gene Expression Regulation, Enzymologic / radiation effects
  • MAP Kinase Signaling System / drug effects
  • MAP Kinase Signaling System / radiation effects
  • Matrix Metalloproteinase 13 / metabolism
  • Mice
  • Oryza / chemistry*
  • Skin Aging / drug effects*
  • Skin Aging / pathology
  • Skin Aging / radiation effects*
  • Ultraviolet Rays / adverse effects*
  • Water / metabolism


  • Water
  • Cyclooxygenase 2
  • Matrix Metalloproteinase 13