In vitro effects of novel type M-V-O derivatives on Xanthine Oxidase

Mustafa Oğuzhan Kaya; Gülşah Çeli K Gül; Figen Kurtuluş

doi:10.14715/cmb/2017.63.12.7

In vitro effects of novel type M-V-O derivatives on Xanthine Oxidase

Cell Mol Biol (Noisy-le-grand). 2017 Dec 30;63(12):25-28. doi: 10.14715/cmb/2017.63.12.7.

Authors

Mustafa Oğuzhan Kaya¹, Gülşah Çeli K Gül², Figen Kurtuluş²

Affiliations

¹ Faculty of Veterinary Medicine, Division of Basic Sciences, Biochemistry Department, Siirt University, Siirt, Turkey.
² Faculty of Arts and Sciences, Department of Chemistry/Inorganic Chemistry Section, BalikesirUniversity, Balikesir Turkey.

PMID: 29307337
DOI: 10.14715/cmb/2017.63.12.7

Abstract

Xanthine Oxidase (XO) is related with different diseases such as vascular, gout, nephropathy and renal stone diseases that are relevant to high uric acid levels and oxidative stress. Some common natural inhibitors of xanthine oxidase are known as rosmarinic acid and apigenin. With this study, we aimed to determine inhibitory effects of originally synthesized new generation transition metal vanadates on Xanthine Oxidase (XO) from bovine milk. Because, Xanthine oxidase inhibitors are typically used in the treatment of gout and nephropathy and renal stone diseases linked to hyperuricaemia. We found considerable IC50 constants for inhibition of XO. Among the synthesized compounds, Cu‒V‒O was found to be the most active (IC50 = 7.119 mM) for inhibition of XO.

Keywords: IC50.; Inhibition; Transition metal; Vanadium; Xanthine Oxidase.

MeSH terms

Enzyme Inhibitors / pharmacology*
Inhibitory Concentration 50
Transition Elements / pharmacology*
Vanadates / pharmacology*
Xanthine Oxidase / antagonists & inhibitors*

Substances

Enzyme Inhibitors
Transition Elements
Vanadates
Xanthine Oxidase