Five rare C32 sesquiterpene lactone dimers with anti-inflammation activity from Vladimiria souliei

Fitoterapia. 2018 Mar:125:117-122. doi: 10.1016/j.fitote.2018.01.002. Epub 2018 Jan 4.

Abstract

Five rare sesquiterpene lactone dimers, vlasouliolides E-I, were isolated from Vladimiria souliei. Their chemical structures were elucidated by spectroscopic analysis. Furthermore, 2 and 4 were unambiguously confirmed by Cu-Kα X-ray crystallographic analysis. Compounds 1, 2, 4 and 5 exhibited significant anti-inflammatory activity against LPS-induced NO production in RAW 264.7 cells with IC50 values of 1.88, 4.89, 7.24 and 2.46μM, respectively. Additionally, compounds 1 and 2 were revealed with potent inhibitory activity of the phosphorylation progress of NF-κB P65.

Keywords: Anti-inflammation; Sesquiterpene lactone dimers; Vladimiria souliei; Vlasouliolides E-I.

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / isolation & purification*
  • Anti-Inflammatory Agents / pharmacology
  • Asteraceae / chemistry*
  • Lactones / isolation & purification*
  • Lactones / pharmacology
  • Mice
  • Molecular Structure
  • Nitric Oxide / metabolism
  • Plant Roots / chemistry
  • RAW 264.7 Cells
  • Sesquiterpenes / isolation & purification*
  • Sesquiterpenes / pharmacology
  • Transcription Factor RelA / metabolism

Substances

  • Anti-Inflammatory Agents
  • Lactones
  • Rela protein, mouse
  • Sesquiterpenes
  • Transcription Factor RelA
  • Nitric Oxide