Curative effect of chemotherapy, KTP lasers, and CO2 lasers combined with chemotherapy in the treatment of adult laryngeal hemangioma

Acta Otolaryngol. 2018 Jun;138(6):567-573. doi: 10.1080/00016489.2017.1419577. Epub 2018 Jan 8.


Purpose: To evaluate three methods for treating adult laryngeal hemangiomas: conventional chemotherapy, CO2 laser combined with chemotherapy, and KTP laser. And to identify risk factors that affected the prognosis of the lesions.

Method: A retrospective analysis was performed on the data from patients with adult laryngeal hemangiomas treated by one of three aforementioned methods, the curative efficacy, and safety of those methods was compared.

Results: All cases were confirmed by suspension micro-laryngoscope examination. Pre- and post-treatment clinical photographs were taken and the outcomes were graded. Thirty-eight patients in 48 different cases were enrolled in the study between June 2010 and June 2016, and some patients were treated more than once. The treatment efficacy of the KTP laser was higher than that of chemotherapy according to the Kruskal-Wallis ANOVA test; however, the ordinal logistic regression showed that the choice of surgical procedure did not affect the treatment results; only the size of the bases of the lesions affected the prognosis of adult laryngeal hemangiomas.

Conclusions: Pingyangmycin injection, KTP laser, and CO2 laser combined with chemotherapy are safe and effective methods for the treatment of adult laryngeal hemangiomas. The size of base of the lesion affects the prognosis of the hemangiomas.

Keywords: CO2 laser; KTP laser; adult laryngeal hemangiomas; chemotherapy.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antineoplastic Agents / therapeutic use*
  • Female
  • Hemangioma / drug therapy
  • Hemangioma / surgery*
  • Humans
  • Laryngeal Neoplasms / drug therapy
  • Laryngeal Neoplasms / surgery*
  • Lasers, Gas / therapeutic use*
  • Lasers, Solid-State / therapeutic use*
  • Male
  • Middle Aged
  • Retrospective Studies
  • Young Adult


  • Antineoplastic Agents