Hexadirectional coding of visual space in human entorhinal cortex

Nat Neurosci. 2018 Feb;21(2):188-190. doi: 10.1038/s41593-017-0050-8. Epub 2018 Jan 8.


Entorhinal grid cells map the local environment, but their involvement beyond spatial navigation remains elusive. We examined human functional MRI responses during a highly controlled visual tracking task and show that entorhinal cortex exhibited a sixfold rotationally symmetric signal encoding gaze direction. Our results provide evidence for a grid-like entorhinal code for visual space and suggest a more general role of the entorhinal grid system in coding information along continuous dimensions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Attention / physiology*
  • Entorhinal Cortex / diagnostic imaging
  • Entorhinal Cortex / physiology*
  • Eye Movements / physiology
  • Female
  • Grid Cells / physiology
  • Humans
  • Image Processing, Computer-Assisted
  • Linear Models
  • Magnetic Resonance Imaging
  • Male
  • Orientation / physiology*
  • Oxygen / blood
  • Space Perception / physiology*
  • Spatial Navigation / physiology*
  • Visual Pathways / diagnostic imaging
  • Visual Pathways / physiology
  • Young Adult


  • Oxygen