Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
, 9 (12), E1088-E1095

Primary Thoracic Extraskeletal Osteosarcoma: A Case Report and Literature Review

Affiliations
Case Reports

Primary Thoracic Extraskeletal Osteosarcoma: A Case Report and Literature Review

Jie Qian et al. J Thorac Dis.

Abstract

Primary extraskeletal osteosarcoma (ESOS) presenting in thoracic locations is very rare and associated with a poor prognosis. The current study presents a case involving a large anterior mediastinal mass, which was histologically confirmed as a primary osteosarcoma. The literature concerning primary thoracic ESOS is reviewed. A total of 60 cases were identified. The median age was 60 years (range, 14-93 years) and males were more prevalent among the reported cases (65%). Survival analysis revealed that the overall 5-year survival was only 22.3%. The majority of cases of thoracic ESOS presented in the lung (n=24, 40%), with others presenting in the mediastinum, pleura, or chest wall. The benefit of surgery, chemotherapy and radiotherapy was confirmed by Cox regression survival analyses.

Keywords: Extraskeletal osteosarcoma; literature review; thoracic.

Conflict of interest statement

Conflicts of Interest: The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Computed tomogram of the lung showed an irregular mass (9.0 cm × 6.4 cm) with accompanying calcification or ossification in the anterior mediastinum.
Figure 2
Figure 2
Microscopic findings show malignant cartilaginous foci. H&E staining. Magnification: (A) ×100; (B) ×200.
Figure 3
Figure 3
(A) Overall survival of all 60 cases of intrathoracic ESOS; (B) survival curves of ESOS patients with different originating sites. The median overall survival for patients with intrathoracic ESOS was 11 months (95% CI: 8.1–13.9) and the 5-year overall survival was 22.3%. ESOS in the mediastinum and lung had a significantly worse overall survival compared with that located in the chest wall or pleural (log-rank P=0.0443).

Similar articles

See all similar articles

Cited by 2 articles

Publication types

Feedback