Effect of substances influencing brain serotonergic transmission on plasma vasopressin levels in the rat

Eur J Pharmacol. 1985 Jul 11;113(1):99-103. doi: 10.1016/0014-2999(85)90347-4.


Studies were carried out in the rat to investigate whether serotonin (5-HT) is involved in the regulation of vasopressin (ADH) release. For this purpose plasma ADH levels were measured in rats treated with drugs enhancing 5-HT transmission, such as d-fenfluramine and quipazine and with 5-HT depleting drugs, p-chlorophenylalanine (PCPA) and 5,7-dihydroxytryptamine (5,7-DHT). Forebrain 5HT, noradrenaline (NA) and dopamine (DA) were also measured. d-Fenfluramine and quipazine induced dose-related increases in plasma ADH levels in normohydrated rats. The effects of quipazine and d-fenfluramine were prevented by PCPA, indicating that 5-HT transmission was required for the biologic response. 5,7-DHT and PCPA pretreatment decreased forebrain 5-HT content and prevented ADH increases involved by water deprivation, suggesting that 5HT is necessary for the hormonal response to osmotic stimuli. The results summarized imply that serotonin may have a role in the physiological release of ADH from neurohypophysis.

MeSH terms

  • 5,7-Dihydroxytryptamine / pharmacology
  • Animals
  • Brain / drug effects*
  • Dose-Response Relationship, Drug
  • Fenclonine / pharmacology
  • Fenfluramine / pharmacology
  • Male
  • Quipazine / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Serotonin / physiology*
  • Vasopressins / blood*


  • Vasopressins
  • Fenfluramine
  • 5,7-Dihydroxytryptamine
  • Serotonin
  • Quipazine
  • Fenclonine