Effect of Noopept on Dynamics of Intracellular Calcium in Neurons of Cultured Rat Hippocampal Slices

Bull Exp Biol Med. 2018 Jan;164(3):330-333. doi: 10.1007/s10517-018-3983-3. Epub 2018 Jan 8.

Abstract

A neuroprotective and nootropic drug Noopept increased the frequency of spontaneous calcium transients in neurons of CA1 radial layer in cultured rat hippocampal slices. In contrast, the drug exerted no significant effect on intracellular calcium concentration and its dynamics in neurons of hippocampal CA1 pyramidal layer.

Keywords: Noopept; fluorescence; hippocampus; intracellular calcium.

MeSH terms

  • Action Potentials / drug effects
  • Animals
  • Animals, Newborn
  • CA1 Region, Hippocampal / cytology
  • CA1 Region, Hippocampal / drug effects*
  • CA1 Region, Hippocampal / metabolism
  • Calcium / metabolism*
  • Dipeptides / pharmacology*
  • Microtomy
  • Neurons / cytology
  • Neurons / drug effects*
  • Neurons / metabolism
  • Neuroprotective Agents / pharmacology*
  • Nootropic Agents / pharmacology
  • Rats
  • Rats, Wistar
  • Tissue Culture Techniques

Substances

  • Dipeptides
  • Neuroprotective Agents
  • Nootropic Agents
  • ethyl phenylacetyl-Pro-Gly
  • Calcium